Title | Autologous hematopoietic cell transplantation for HIV-related lymphoma: results of the BMT CTN 0803/AMC 071 trial. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Alvarnas, JC, Le Rademacher, J, Wang, Y, Little, RF, Akpek, G, Ayala, E, Devine, S, Baiocchi, R, Lozanski, G, Kaplan, L, Noy, A, Popat, U, Hsu, J, Morris, LE, Thompson, J, Horowitz, MM, Mendizabal, A, Levine, A, Krishnan, A, Forman, SJ, Navarro, WH, Ambinder, R |
Journal | Blood |
Volume | 128 |
Issue | 8 |
Pagination | 1050-8 |
Date Published | 2016 08 25 |
ISSN | 1528-0020 |
Keywords | Adult, Bone Marrow Transplantation, CD4 Lymphocyte Count, Databases as Topic, Demography, Disease-Free Survival, Female, Hematopoietic Stem Cell Transplantation, Humans, Lymphoma, AIDS-Related, Male, Middle Aged, Transplantation, Autologous, Treatment Outcome, Viral Load, Young Adult |
Abstract | Autologous hematopoietic cell transplant (AHCT) for HIV-infected patients is largely limited to centers with HIV-specific expertise. The Blood and Marrow Transplant Clinical Trials Network 0803/AIDS Malignancy Consortium 071 trial is a multicenter phase 2 study of AHCT for patients with HIV-related lymphoma (HRL). Eligible patients had chemotherapy-sensitive relapsed/persistent HRL, were >15 years of age, and had treatable HIV infection. Patients were prepared using carmustine, etoposide, cytarabine, and melphalan and received consistent management of peritransplant antiretroviral treatment. The primary endpoint was 1-year overall survival. Forty-three patients were enrolled; 40 underwent AHCT. Pretransplant HIV viral load was undetectable ( |
DOI | 10.1182/blood-2015-08-664706 |
Alternate Journal | Blood |
PubMed ID | 27297790 |
PubMed Central ID | PMC5000843 |
Grant List | U10 HL069294 / HL / NHLBI NIH HHS / United States K12 HD001399 / HD / NICHD NIH HHS / United States U10 HL069278 / HL / NHLBI NIH HHS / United States U24 CA076518 / CA / NCI NIH HHS / United States UG1 HL069278 / HL / NHLBI NIH HHS / United States U10 HL069310 / HL / NHLBI NIH HHS / United States U10 HL109137 / HL / NHLBI NIH HHS / United States P30 CA008748 / CA / NCI NIH HHS / United States UM1 CA121947 / CA / NCI NIH HHS / United States U01 CA121947 / CA / NCI NIH HHS / United States |