Characteristics of CliniMACS® System CD34-enriched T cell-depleted grafts in a multicenter trial for acute myeloid leukemia-Blood and Marrow Transplant Clinical Trials Network (BMT CTN) protocol 0303.

TitleCharacteristics of CliniMACS® System CD34-enriched T cell-depleted grafts in a multicenter trial for acute myeloid leukemia-Blood and Marrow Transplant Clinical Trials Network (BMT CTN) protocol 0303.
Publication TypeJournal Article
Year of Publication2012
AuthorsKeever-Taylor, CA, Devine, SM, Soiffer, RJ, Mendizabal, A, Carter, S, Pasquini, MC, Hari, PN, Stein, A, Lazarus, HM, Linker, C, Goldstein, SC, Stadtmauer, EA, O'Reilly, RJ
JournalBiol Blood Marrow Transplant
Volume18
Issue5
Pagination690-7
Date Published2012 May
ISSN1523-6536
KeywordsAntigens, CD34, Blood Component Removal, Bone Marrow Transplantation, CD3 Complex, Flow Cytometry, Graft Survival, Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Transplantation, Humans, Immunomagnetic Separation, Leukemia, Myeloid, Acute, Longitudinal Studies, Lymphocyte Count, Lymphocyte Depletion, Multivariate Analysis, Siblings, T-Lymphocytes, Transplantation, Homologous
Abstract

Eight centers participated in the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) protocol 0303 to determine the effect of extensive T cell depletion (TCD) on the outcome of HLA matched sibling donor transplantation for acute myeloid leukemia. One goal of the study was to determine if TCD could be performed uniformly among study sites. TCD was achieved using the CliniMACS(®) CD34 Reagent System for CD34 enrichment. Processed grafts needed to contain ≥ 2.0 × 10(6) CD34(+)cells/kg with a target of 5.0 × 10(6) CD34(+) cells/kg and

DOI10.1016/j.bbmt.2011.08.017
Alternate JournalBiol Blood Marrow Transplant
PubMed ID21875505
PubMed Central IDPMC3762249
Grant ListU10 HL069294 / HL / NHLBI NIH HHS / United States
UG1 HL069286 / HL / NHLBI NIH HHS / United States
U10 HL069330 / HL / NHLBI NIH HHS / United States
U10 HL069249 / HL / NHLBI NIH HHS / United States
U01 HL069294-01 / HL / NHLBI NIH HHS / United States
U01 HL069294 / HL / NHLBI NIH HHS / United States
U10 HL069348 / HL / NHLBI NIH HHS / United States
U24 CA076518 / CA / NCI NIH HHS / United States
U10 HL069286 / HL / NHLBI NIH HHS / United States
U01HL069294 / HL / NHLBI NIH HHS / United States