|Title||Design of a cost-effectiveness analysis alongside a randomized trial of transplantation using umbilical cord blood versus HLA-haploidentical related bone marrow in advanced hematologic cancer.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Roth, JA, Bensink, ME, O'Donnell, PV, Fuchs, EJ, Eapen, M, Ramsey, SD|
|Journal||J Comp Eff Res|
|Date Published||2014 Mar|
|Keywords||Adolescent, Adult, Aged, Bone Marrow Transplantation, Comparative Effectiveness Research, Cord Blood Stem Cell Transplantation, Cost-Benefit Analysis, Female, Health Care Costs, Health Expenditures, Hematologic Neoplasms, Humans, Male, Middle Aged, Quality of Life, Young Adult|
BACKGROUND: BMT CTN 1101 is a Phase III randomized controlled trial evaluating the comparative effectiveness of double unrelated umbilical cord blood (dUCB) versus HLA-haploidentical related donor bone marrow (haplo-BM) donor cell sources for blood or bone marrow transplantation (BMT) in patients with hematologic malignancies. Herein, we present the rationale, design and methods of the first cost-effectiveness analysis to be conducted alongside a BMT trial.
METHODS: Consenting patients will provide health insurance information to allow calculation of direct medical costs from reimbursement records, and will provide out-of-pocket costs, time costs and health-related quality of life measures through an online survey. These outcomes will inform a cost-effectiveness analysis comparing dUCB and haplo-BM donor cell sources from patient, payer and societal perspectives.
CONCLUSION: Novel approaches may significantly change the cost, outcomes or availability of BMT. The results of this analysis will be the first to provide a comprehensive evaluation of the comparative effectiveness of these approaches from multiple perspectives.
|Alternate Journal||J Comp Eff Res|
|PubMed Central ID||PMC4036637|
|Grant List||U10 HL069294 / HL / NHLBI NIH HHS / United States |
U10 HL069290 / HL / NHLBI NIH HHS / United States
U24 CA076518 / CA / NCI NIH HHS / United States
U10 HL069301 / HL / NHLBI NIH HHS / United States
U10 HL069310 / HL / NHLBI NIH HHS / United States
R01 HL116291 / HL / NHLBI NIH HHS / United States
T32 AG027677 / AG / NIA NIH HHS / United States
U10 CA180828 / CA / NCI NIH HHS / United States
U10HL069294 / HL / NHLBI NIH HHS / United States
R01HL116291-01 / HL / NHLBI NIH HHS / United States
U10 HL069330 / HL / NHLBI NIH HHS / United States