Title | Design of a cost-effectiveness analysis alongside a randomized trial of transplantation using umbilical cord blood versus HLA-haploidentical related bone marrow in advanced hematologic cancer. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Roth, JA, Bensink, ME, O'Donnell, PV, Fuchs, EJ, Eapen, M, Ramsey, SD |
Journal | J Comp Eff Res |
Volume | 3 |
Issue | 2 |
Pagination | 135-44 |
Date Published | 2014 Mar |
ISSN | 2042-6313 |
Keywords | Adolescent, Adult, Aged, Bone Marrow Transplantation, Comparative Effectiveness Research, Cord Blood Stem Cell Transplantation, Cost-Benefit Analysis, Female, Health Care Costs, Health Expenditures, Hematologic Neoplasms, Humans, Male, Middle Aged, Quality of Life, Young Adult |
Abstract | BACKGROUND: BMT CTN 1101 is a Phase III randomized controlled trial evaluating the comparative effectiveness of double unrelated umbilical cord blood (dUCB) versus HLA-haploidentical related donor bone marrow (haplo-BM) donor cell sources for blood or bone marrow transplantation (BMT) in patients with hematologic malignancies. Herein, we present the rationale, design and methods of the first cost-effectiveness analysis to be conducted alongside a BMT trial. METHODS: Consenting patients will provide health insurance information to allow calculation of direct medical costs from reimbursement records, and will provide out-of-pocket costs, time costs and health-related quality of life measures through an online survey. These outcomes will inform a cost-effectiveness analysis comparing dUCB and haplo-BM donor cell sources from patient, payer and societal perspectives. CONCLUSION: Novel approaches may significantly change the cost, outcomes or availability of BMT. The results of this analysis will be the first to provide a comprehensive evaluation of the comparative effectiveness of these approaches from multiple perspectives. |
DOI | 10.2217/cer.13.95 |
Alternate Journal | J Comp Eff Res |
PubMed ID | 24645687 |
PubMed Central ID | PMC4036637 |
Grant List | U10 HL069294 / HL / NHLBI NIH HHS / United States U10 HL069290 / HL / NHLBI NIH HHS / United States U24 CA076518 / CA / NCI NIH HHS / United States U10 HL069301 / HL / NHLBI NIH HHS / United States U10 HL069310 / HL / NHLBI NIH HHS / United States R01 HL116291 / HL / NHLBI NIH HHS / United States T32 AG027677 / AG / NIA NIH HHS / United States U10 CA180828 / CA / NCI NIH HHS / United States U10HL069294 / HL / NHLBI NIH HHS / United States R01HL116291-01 / HL / NHLBI NIH HHS / United States U10 HL069330 / HL / NHLBI NIH HHS / United States |