Title | Immune Recovery Following Autologous Hematopoietic Stem Cell Transplantation in HIV-Related Lymphoma Patients on the BMT CTN 0803/AMC 071 Trial. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Shindiapina, P, Pietrzak, M, Seweryn, M, McLaughlin, E, Zhang, X, Makowski, M, Ahmed, EHassan, Schlotter, S, Pearson, R, Kitzler, R, Mozhenkova, A, Le-Rademacher, J, Little, RF, Akpek, G, Ayala, E, Devine, SM, Kaplan, LD, Noy, A, Popat, UR, Hsu, JW, Morris, LE, Mendizabal, AM, Krishnan, A, Wachsman, W, Williams, N, Sharma, N, Hofmeister, CC, Forman, SJ, Navarro, WH, Alvarnas, JC, Ambinder, RF, Lozanski, G, Baiocchi, RA |
Journal | Front Immunol |
Volume | 12 |
Pagination | 700045 |
Date Published | 2021 |
ISSN | 1664-3224 |
Keywords | Clinical Trials, Phase II as Topic, Hematopoietic Stem Cell Transplantation, HIV Infections, Humans, Immune Reconstitution, Lymphoma, AIDS-Related, Transplantation, Autologous |
Abstract | We report a first in-depth comparison of immune reconstitution in patients with HIV-related lymphoma following autologous hematopoietic cell transplant (AHCT) recipients (n=37, lymphoma, BEAM conditioning), HIV(-) AHCT recipients (n=30, myeloma, melphalan conditioning) at 56, 180, and 365 days post-AHCT, and 71 healthy control subjects. Principal component analysis showed that immune cell composition in HIV(+) and HIV(-) AHCT recipients clustered away from healthy controls and from each other at each time point, but approached healthy controls over time. Unsupervised feature importance score analysis identified activated T cells, cytotoxic memory and effector T cells [higher in HIV(+)], and naïve and memory T helper cells [lower HIV(+)] as a having a significant impact on differences between HIV(+) AHCT recipient and healthy control lymphocyte composition (p |
DOI | 10.3389/fimmu.2021.700045 |
Alternate Journal | Front Immunol |
PubMed ID | 34539628 |
PubMed Central ID | PMC8446430 |
Grant List | U01 CA121947 / CA / NCI NIH HHS / United States U10 HL069294 / HL / NHLBI NIH HHS / United States T32 CA009338 / CA / NCI NIH HHS / United States P30 CA016058 / CA / NCI NIH HHS / United States UM1 CA121947 / CA / NCI NIH HHS / United States T32 CA090223 / CA / NCI NIH HHS / United States |