Title | Low EGF in myeloablative allotransplantation: association with severe acute GvHD in BMT CTN 0402. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Holtan, SG, Newell, LF, Cutler, C, Verneris, MR, DeFor, TE, Wu, J, Howard, A, MacMillan, ML, Antin, JH, Blazar, BR, Weisdorf, DJ, Panoskaltsis-Mortari, A |
Journal | Bone Marrow Transplant |
Volume | 52 |
Issue | 9 |
Pagination | 1300-1303 |
Date Published | 2017 Sep |
ISSN | 1476-5365 |
Keywords | Adult, Bone Marrow Transplantation, Epidermal Growth Factor, Female, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Male, Middle Aged, Transplantation Conditioning, Vascularized Composite Allotransplantation |
Abstract | Epidermal growth factor (EGF) is a recently described biomarker of acute GvHD (aGvHD). Whether low plasma EGF prior to hematopoietic cell transplantation (HCT) predisposes to the development of aGvHD, or whether EGF levels fall because of severe aGvHD, is unknown. To evaluate this, we tested plasma samples collected at pre-HCT baseline, day +28 and day +100 during the course of the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0402. We found that baseline EGF plasma concentrations were three-fold lower in HCT recipients compared to donors (24.3 vs 76.0 pg/mL, P |
DOI | 10.1038/bmt.2017.89 |
Alternate Journal | Bone Marrow Transplant |
PubMed ID | 28581470 |
PubMed Central ID | PMC5699445 |
Grant List | U10 HL069294 / HL / NHLBI NIH HHS / United States UG1 HL069290 / HL / NHLBI NIH HHS / United States P30 CA077598 / CA / NCI NIH HHS / United States UG1 HL069249 / HL / NHLBI NIH HHS / United States U24 CA076518 / CA / NCI NIH HHS / United States R37 AI034495 / AI / NIAID NIH HHS / United States UG1 HL109137 / HL / NHLBI NIH HHS / United States |