Title | A refined risk score for acute graft-versus-host disease that predicts response to initial therapy, survival, and transplant-related mortality. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | MacMillan, ML, Robin, M, Harris, AC, DeFor, TE, Martin, PJ, Alousi, A, Ho, VT, Bolaños-Meade, J, Ferrara, JLM, Jones, R, Arora, M, Blazar, BR, Holtan, SG, Jacobsohn, D, Pasquini, M, Socie, G, Antin, JH, Levine, JE, Weisdorf, DJ |
Journal | Biol Blood Marrow Transplant |
Volume | 21 |
Issue | 4 |
Pagination | 761-7 |
Date Published | 2015 Apr |
ISSN | 1523-6536 |
Keywords | Acute Disease, Adolescent, Adult, Aged, Allografts, Child, Child, Preschool, Disease-Free Survival, Female, Graft vs Host Disease, Hematologic Neoplasms, Humans, Infant, Male, Middle Aged, Risk Factors, Stem Cell Transplantation, Survival Rate |
Abstract | To develop a novel acute graft-versus-host disease (GVHD) risk score, we examined the GVHD clinical stage and grade of 1723 patients at the onset of treatment with systemic steroids. Using clinical grouping, descriptive statistics and recursive partitioning, we identified poorly responsive, high-risk (HR) acute GVHD by the number of involved organs and severity of GVHD at onset. The overall response (complete response/partial response) rate 28 days after initiation of steroid therapy for acute GVHD was lower in the 269 patients with HR-GVHD than in the 1454 patients with standard risk (SR)-GVHD (44% [95% confidence interval (CI) 38% to 50%] versus 68% [95% CI, 66% to 70%], P |
DOI | 10.1016/j.bbmt.2015.01.001 |
Alternate Journal | Biol Blood Marrow Transplant |
PubMed ID | 25585275 |
PubMed Central ID | PMC4359643 |
Grant List | U10 HL069294 / HL / NHLBI NIH HHS / United States UG1 HL069286 / HL / NHLBI NIH HHS / United States P30 CA077598 / CA / NCI NIH HHS / United States U10 HL069290 / HL / NHLBI NIH HHS / United States U10 HL069330 / HL / NHLBI NIH HHS / United States U10 HL069310 / HL / NHLBI NIH HHS / United States U10HL069290 / HL / NHLBI NIH HHS / United States U10 HL109526 / HL / NHLBI NIH HHS / United States P30 CA016672 / CA / NCI NIH HHS / United States UL1 TR002494 / TR / NCATS NIH HHS / United States P01 CA065493 / CA / NCI NIH HHS / United States U24 CA076518 / CA / NCI NIH HHS / United States U10 HL069286 / HL / NHLBI NIH HHS / United States U10 HL069249 / HL / NHLBI NIH HHS / United States U10 HL069334 / HL / NHLBI NIH HHS / United States U10 HL109137 / HL / NHLBI NIH HHS / United States 2P01CA065493 / CA / NCI NIH HHS / United States |