Summary of the 2019 Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling.

TitleSummary of the 2019 Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling.
Publication TypeJournal Article
Year of Publication2020
AuthorsHolstein, SA, Howard, A, Avigan, D, Bhutani, M, Cohen, AD, Costa, LJ, Dhodapkar, MV, Gay, F, Gormley, N, Green, DJ, Hillengass, J, Korde, N, Li, Z, Mailankody, S, Neri, P, Parekh, S, Pasquini, MC, Puig, N, G Roodman, D, Samur, MKemal, Shah, N, Shah, UA, Shi, Q, Spencer, A, Suman, VJ, Usmani, SZ, McCarthy, PL
JournalBiol Blood Marrow Transplant
Volume26
Issue10
Paginatione247-e255
Date Published2020 10
ISSN1523-6536
KeywordsBone Marrow, Humans, Multiple Myeloma, Neoplasm, Residual
Abstract

The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Myeloma Intergroup has organized an annual workshop focused on minimal residual disease (MRD) testing and immune profiling (IP) in multiple myeloma since 2016. In 2019, the workshop took place as an American Society of Hematology (ASH) Friday Scientific Workshop titled "Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma." This workshop focused on 4 main topics: the molecular and immunologic evolution of plasma cell disorders, development of new laboratory- and imaging-based MRD assessment approaches, chimeric antigen receptor T cell therapy research, and statistical and regulatory issues associated with novel clinical endpoints. In this report, we provide a summary of the workshop and discuss future directions.

DOI10.1016/j.bbmt.2020.06.011
Alternate JournalBiol Blood Marrow Transplant
PubMed ID32589921
PubMed Central IDPMC7529908
Grant ListU10 HL069294 / HL / NHLBI NIH HHS / United States
R01 CA241677 / CA / NCI NIH HHS / United States
R01 CA209882 / CA / NCI NIH HHS / United States
UL1 TR001863 / TR / NCATS NIH HHS / United States
UG1 HL138645 / HL / NHLBI NIH HHS / United States
IK6 BX004596 / BX / BLRD VA / United States
P30 CA008748 / CA / NCI NIH HHS / United States
R01 AR059679 / AR / NIAMS NIH HHS / United States
U24 CA076518 / CA / NCI NIH HHS / United States
U24 HL138660 / HL / NHLBI NIH HHS / United States