|Title||Voriconazole pharmacokinetics following HSCT: results from the BMT CTN 0101 trial.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Hope, WW, Walsh, TJ, Goodwin, J, Peloquin, CA, Howard, A, Kurtzberg, J, Mendizabal, A, Confer, DL, Bulitta, J, Baden, LR, Neely, MN, Wingard, JR|
|Corporate Authors||Blood and Marrow Transplant Clinical Trials Network|
|Journal||J Antimicrob Chemother|
|Date Published||2016 08|
|Keywords||Adolescent, Adult, Aged, Antifungal Agents, Area Under Curve, Double-Blind Method, Female, Humans, Male, Middle Aged, Plasma, Prospective Studies, Voriconazole, Young Adult|
BACKGROUND: Voriconazole is a first-line agent for the prevention and treatment of a number of invasive fungal diseases. Relatively little is known about the relationship between drug exposure and the prevention of invasive fungal infections.
PATIENTS AND METHODS: A pharmacokinetic-pharmacodynamic substudy was performed as part of the BMT CTN 0101 trial, which was a randomized clinical trial comparing voriconazole with fluconazole for the prevention of invasive fungal infections in HSCT recipients. A previously described population pharmacokinetic model was used to calculate the maximum a posteriori Bayesian estimates for 187 patients. Drug exposure in each patient was quantified in terms of the average AUC and average trough concentrations. The relationship between drug exposure and the probability of breakthrough infection was investigated using logistic regression. AUC and trough concentrations in patients with and without breakthrough infection were compared.
RESULTS: Pharmacokinetic data from each patient were readily described using the maximum a posteriori Bayesian estimates. There were only five patients that had a breakthrough infection while receiving voriconazole in the first 100 days post-HSCT. For these patients, there was no statistically significant relationship between the average AUC or average trough concentration and the probability of breakthrough infection [OR (95% CI) 1.026 (0.956-1.102) and 1.108 (0.475-2.581), respectively]. P value for these estimates was 0.474 and 0.813, respectively.
CONCLUSIONS: Given the very small number of proven/probable infections, it was difficult to identify any differences in drug exposure in HSCT recipients with and without breakthrough fungal infections.
|Alternate Journal||J Antimicrob Chemother|
|PubMed Central ID||PMC4954923|
|Grant List||U10 HL069294 / HL / NHLBI NIH HHS / United States |
U10 HL069274 / HL / NHLBI NIH HHS / United States
U24 CA076518 / CA / NCI NIH HHS / United States
U10 HL069310 / HL / NHLBI NIH HHS / United States
U10 HL109137 / HL / NHLBI NIH HHS / United States
UG1 HL069274 / HL / NHLBI NIH HHS / United States